Papers

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Protein-enriched familiar foods and drinks improve protein intake of hospitalized older patients: A randomized controlled trial

Cilincal Nutrition  | 12-05-2017 | Abstract Background & aims: Adequate protein intake is important in preventing and treating undernutrition. Hospitalized older patients are recommended to consume 1.2e1.5 g of protein per kg body weight per day (g/kg/d) but most of them fail to do so. Therefore, we investigated whether a range of newly [...]

By |2018-01-08T13:07:28+01:00juni 20th, 2017|Papers|Reacties uitgeschakeld voor Protein-enriched familiar foods and drinks improve protein intake of hospitalized older patients: A randomized controlled trial

The Dietary Approaches to Stop Hypertension Diet, Cognitive Function, and Cognitive Decline in American Older Women

JAMDA | 01-06-2017 |   Abstract Objectives: To examine the association between long-term adherence to the Dietary Approaches to Stop Hypertension (DASH) diet with cognitive function and decline in older American women. Design: Prospective cohort study. Setting: The Nurses’ Health Study, a cohort of registered nurses residing in 11 US states. Participants: A [...]

By |2018-01-08T13:08:05+01:00juni 20th, 2017|Papers|Reacties uitgeschakeld voor The Dietary Approaches to Stop Hypertension Diet, Cognitive Function, and Cognitive Decline in American Older Women

Dose response effects of supplementation with calcifediol on serum 25-hydroxyvitamin D status and its metabolites: A randomized controlled trial in older adults

Clinical Nutrition | 26-03-2017 | Abstract Background & aims: Oral supplementation with vitamin D is recommended for older adults to maintain a sufficient 25-hydroxyvitamin D (25(OH)D) status throughout the year. While supplementation with vitamin D2 or D3 is most common, alternative treatment regimens exist which require further investigation with respect to increasing 25(OH)D [...]

By |2018-01-08T13:08:41+01:00juni 20th, 2017|Papers|Reacties uitgeschakeld voor Dose response effects of supplementation with calcifediol on serum 25-hydroxyvitamin D status and its metabolites: A randomized controlled trial in older adults

Activation-Induced Autophagy Is Preserved in CD4+ T-Cells in Familial Longevity

The Journal of Gerontology  | 09-05-2017 | Abstract As with many other tissues and organs, the immune system is also affected by age. Immunosenescence is characterized by a decreased ability of immune cells to mount a productive response upon exposure to new antigens. Several studies have reported that members of families with exceptional [...]

By |2018-01-08T13:09:22+01:00juni 19th, 2017|Papers|Reacties uitgeschakeld voor Activation-Induced Autophagy Is Preserved in CD4+ T-Cells in Familial Longevity

Cellular senescence drives age-dependent hepatic steatosis

Nature Communications | 13-06-2017 | Abstract: The incidence of non-alcoholic fatty liver disease (NAFLD) increases with age. Cellular senescence refers to a state of irreversible cell-cycle arrest combined with the secretion of proinflammatory cytokines and mitochondrial dysfunction. Senescent cells contribute to age-related tissue degeneration. Here we show that the accumulation of senescent cells promotes [...]

By |2018-01-08T13:09:59+01:00juni 19th, 2017|Papers|Reacties uitgeschakeld voor Cellular senescence drives age-dependent hepatic steatosis

Later-life mortality and longevity in late-18th and 19th-century cohort: Where are we now, and where are we heading

European Historical Population Samples Network  | 31-01-2017 | Abstract The limits to human lifespan are a widely discussed topic. Yet, later-life mortality and longevity are generally studied from a genetic perspective, while the social dimension has received less attention. This paper gives a systematic overview of trends in later-life mortality and longevity for cohorts [...]

By |2018-01-08T13:10:37+01:00april 4th, 2017|Papers|Reacties uitgeschakeld voor Later-life mortality and longevity in late-18th and 19th-century cohort: Where are we now, and where are we heading

Targeted Apoptosis of Senescent Cells Restores Tissue Homeostasis in Response to Chemotoxicity and Aging

Cell  | March 2017 | Abstract The accumulation of irreparable cellular damage restricts healthspan after acute stress or natural aging. Senescent cells are thought to impair tissue function and their genetic clearance can delay features of aging. Identifying how senescent cells avoid apoptosis allows for the prospective design of anti-senescence compounds to address whether homeostasis [...]

By |2017-06-19T12:30:09+01:00maart 7th, 2017|Papers|Reacties uitgeschakeld voor Targeted Apoptosis of Senescent Cells Restores Tissue Homeostasis in Response to Chemotoxicity and Aging

Employing biomarkers of healthy ageing for leveraging genetic studies into human longevity

Experimental Gerontology  | 29-06-2016 | Abstract: Genetic studies have thus far identified a limited number of loci associated with human longevity by applying age at death or survival up to advanced ages as phenotype. As an alternative approach, one could first try to identify biomarkers of healthy ageing and the genetic variants associated with [...]

By |2017-06-19T12:31:20+01:00februari 21st, 2017|Papers|Reacties uitgeschakeld voor Employing biomarkers of healthy ageing for leveraging genetic studies into human longevity

Resistance Training Increases Skeletal Muscle Capillarization in Healthy Older Men

Medicine and science in sports and exercise  | November 2016 |  Abstract: PURPOSE: Skeletal muscle capillarization plays a key role in oxygen and nutrient delivery to muscle. The loss of muscle mass with aging and the concept of anabolic resistance have been, at least partly, attributed to changes in skeletal muscle capillary structure and [...]

By |2017-06-19T12:32:09+01:00februari 20th, 2017|Papers|Reacties uitgeschakeld voor Resistance Training Increases Skeletal Muscle Capillarization in Healthy Older Men

Expression of protocadherin gamma in skeletal muscle tissue is associated with age and muscle weakness

J Cachexia Sarcopenia Muscle  |  December 2016 |  Abstract BACKGROUND: The skeletal muscle system plays an important role in the independence of older adults. In this study we examine differences in the skeletal muscle transcriptome between healthy young and older subjects and (pre-)frail older adults. Additionally, we examine the effect of resistance-type exercise training [...]

By |2017-06-19T12:32:57+01:00februari 20th, 2017|Papers|Reacties uitgeschakeld voor Expression of protocadherin gamma in skeletal muscle tissue is associated with age and muscle weakness