Eline Slagboom en collega’s publiceren Review in Nature over verouderingsonderzoek

Facing up to the global challenges of ageing Linda Partridge, Joris Deelen & P. Eline Slagboom Longer human lives have led to a global burden of late-life disease. However, some older people experience little ill health, a trait that should be extended to the general population. Interventions into lifestyle, including increased exercise and reduction in food intake and obesity, can help to maintain healthspan. Altered gut microbiota, removal of senescent cells, blood factors obtained from young individuals [...]

september 6th, 2018|

Cell Symposium on Aging and Metabolism – September 23-25 2018 | Spain

As organisms age, change over time occurs as a layered process, from molecular modifications to shifts in tissue homeostasis, ultimately leading to systemic transformations. Alterations in metabolism are found throughout the hierarchy of change and can be integral to the relationship between aging and disease as well as to the impact of aging on physiological processes such as inflammation and immunity.  Recent studies have provided new insight into how the perturbation of metabolic factors can [...]

augustus 13th, 2018|

LASA-onderzoek wijst uit: Ouderen steeds minder eenzaam. Meer eenzame ouderen.

LASA-onderzoek wijst uit Ouderen steeds minder eenzaam. Meer eenzame ouderen. 15 juni 2018 Ouderen in Nederland voelen zich minder eenzaam dan 20 jaar geleden. De gemiddelde eenzaamheid van Nederlanders van 55 jaar en ouder daalde tussen 1996 en 2016. Eenzaamheid van ouderen neemt echter toe met de leeftijd. Daarom zijn er, vanwege de toename van de oudere bevolking, in 2016 wel méér eenzame ouderen in Nederland dan in 1996. Dit blijkt uit de gegevens [...]

juli 9th, 2018|

Worms may hold the secret to longer life

Horizon - The EU Research & Innovation Magazine 5 juli 2018 The regenerative abilities of the flatworm Macrostomum lignano serve as a model for how humans might regenerate tissues. Image credit - Flickr/ Lukas Schärer, licensed under CC BY-SA 2.0 Research into the remarkable regenerative powers of worms and the insights they can give into battling diseases could help humans live longer and healthier lives. Humans have long dreamed of finding the secret to [...]

juli 9th, 2018|

Reduced expression of C/EBPβ-LIP extends health and lifespan in mice

E life Sciences| 30 april 2018 Abstract Ageing is associated with physical decline and the development of age-related diseases such as metabolic disorders and cancer. Few conditions are known that attenuate the adverse effects of ageing, including calorie restriction (CR) and reduced signalling through the mechanistic target of rapamycin complex 1 (mTORC1) pathway. Synthesis of the metabolic transcription factor C/EBPβ-LIP is stimulated by mTORC1, which critically depends on a short upstream open reading frame [...]

juni 25th, 2018|

Twintig jaar lang leven in Leiden

13 juni 2018• NIEUWSBERICHT LUMC Corpus Leiden was op zaterdag 9 juni 2018 het toneel voor een bijzondere bijeenkomst: 430 deelnemers aan de Leiden Lang Leven Studie kwamen bij elkaar voor een deelnemersdag. Onderzoekers van het Leids Universitair Medisch Centrum (LUMC) praatten hen bij over diverse facetten van het verouderingsonderzoek: het centrale onderwerp van de Leiden LangLeven Studie (LLS). Na een introductie van prof. dr. Eline Slagboom over de wetenschappelijke inzichten die twintig jaar [...]

juni 18th, 2018|

Longevity mainly ascribed to an extremely long-lived mother

For many years, scientists in Leiden have been monitoring 421 exceptional families with several members who have lived way beyond the age of 90. A new analysis of these extremely long-lived persons, their siblings, and parents now shows that longevity in these families is passed on mainly through the mother. The researchers present their results in the scientific journal The Journal of Gerontology: Biological Sciences. (press release LUMC) ‘From our analysis of the 944 extremely long-lived [...]

april 11th, 2018|

Scientific Conference – Longitudinal Studies – Genome Campus Hinxton

30 May-1 June 2018 - Wellcome Genome Campus, Hinxton, UK Longitudinal studies are ideal tools for studying age-related functional changes, and the development and progression of chronic diseases. This conference will bring together scientists working on studies in childhood, adult and late life to identify novel biomarkers of functional decline and development of disease susceptibility, and to understand the lifetime drivers and underlying pathways of these processes. The programme will showcase new findings, methods [...]

maart 14th, 2018|

News from the board – Public Private Partnership (PPPs)

One of the activities for 2018 that DuSRA is trying to launch,  is to set up a public private partnership in the field of ageing. The board submitted an initial concept to ZonMW to get the oppurtunity to be selected in the proposition of ZonMW and the Topsectors. The initiative called VOILA: Vitality Oriented Innovations for the Lifecourse of the Ageing Society, has indeed been chosen for further development. At the moment we are working [...]

maart 13th, 2018|

 Postdoctoral Positions in Human Functional Genomics of Aging and Disease – Albert Einstein College of Medicine

The Suh Laboratory at the Albert Einstein College of Medicine is actively seeking 3-4 highly motivated postdoctoral fellows interested in any of the following areas: (1) Genetics of Human Aging-Related Disease including Alzheimer’s Disease. (2) Genome Maintenance/Cellular Senescence in Aging and Disease. (3) Computational and Bioinformatics Approaches to Human Aging and Disease. Research focus: The Sub lab is interested in understanding genetic and molecular mechanisms that underlie the interface of intrinsic aging and disease [...]

maart 13th, 2018|