Papers

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Eline Slagboom en collega’s publiceren Review in Nature over verouderingsonderzoek

Facing up to the global challenges of ageing Linda Partridge, Joris Deelen & P. Eline Slagboom Longer human lives have led to a global burden of late-life disease. However, some older people experience little ill health, a trait that should be extended to the general population. Interventions into lifestyle, including increased exercise and reduction in food intake [...]

By |2018-09-10T12:18:54+00:00september 6th, 2018|Nieuws, Papers|Reacties uitgeschakeld voor Eline Slagboom en collega’s publiceren Review in Nature over verouderingsonderzoek

Worms may hold the secret to longer life

Horizon - The EU Research & Innovation Magazine 5 juli 2018 The regenerative abilities of the flatworm Macrostomum lignano serve as a model for how humans might regenerate tissues. Image credit - Flickr/ Lukas Schärer, licensed under CC BY-SA 2.0 Research into the remarkable regenerative powers of worms and the insights they can give [...]

By |2018-08-20T14:23:05+00:00juli 9th, 2018|Nieuws, Papers|Reacties uitgeschakeld voor Worms may hold the secret to longer life

Reduced expression of C/EBPβ-LIP extends health and lifespan in mice

E life Sciences| 30 april 2018 Abstract Ageing is associated with physical decline and the development of age-related diseases such as metabolic disorders and cancer. Few conditions are known that attenuate the adverse effects of ageing, including calorie restriction (CR) and reduced signalling through the mechanistic target of rapamycin complex 1 (mTORC1) pathway. Synthesis [...]

By |2018-06-25T10:26:15+00:00juni 25th, 2018|Nieuws, Papers|Reacties uitgeschakeld voor Reduced expression of C/EBPβ-LIP extends health and lifespan in mice

DNA methylation as a mediator of the association between prenatal adversity and risk factors for metabolic disease in adulthood

Science Advances | 03-01-2018 Abstract Although it is assumed that epigenetic mechanisms, such as changes in DNA methylation (DNAm), underlie the relationship between adverse intrauterine conditions and adult metabolic health, evidence from human studies remains scarce. Therefore, we evaluated whether DNAm in whole blood mediated the association between prenatal famine exposure and metabolic health [...]

By |2018-02-05T14:27:14+00:00februari 5th, 2018|Nieuws, Papers|Reacties uitgeschakeld voor DNA methylation as a mediator of the association between prenatal adversity and risk factors for metabolic disease in adulthood

A p300 and SIRT1 Regulated Acetylation Switch of C/EBPa Controls Mitochondrial Function

Cell Press  | 9 januari 2018 | Summary Cellular metabolism is a tightly controlled process in which the cell adapts fluxes through metabolic  pathways in response to changes in nutrient supply. Among the transcription factors that regulate  gene expression and thereby cause changes in cellular metabolism is the basic leucine-zipper (bZIP) transcription factor CCAAT/enhancer-binding [...]

By |2018-01-22T10:08:27+00:00januari 22nd, 2018|Nieuws, Papers|Reacties uitgeschakeld voor A p300 and SIRT1 Regulated Acetylation Switch of C/EBPa Controls Mitochondrial Function

Plasticity of lifelong calorie-restricted C57BL/6J mice in adapting to a medium-fat diet intervention at old age

Aging Cell | 23-09-2017| Summary Calorie restriction (CR) is a dietary regimen that supports healthy aging. In this study, we investigated the systemic and liver-specific responses caused by a diet switch to a medium-fat (MF) diet in 24-month-old lifelong, CR-exposed mice. This study aimed to increase the knowledge base on dietary alterations of [...]

By |2018-01-08T13:04:22+00:00januari 8th, 2018|Papers|Reacties uitgeschakeld voor Plasticity of lifelong calorie-restricted C57BL/6J mice in adapting to a medium-fat diet intervention at old age

Prolonged high-fat diet induces gradual and fat depot-specific DNA methylation changes in adult mice

Scientific reports | 03-03-2017 | Abstract High-fat diets (HFD) are thought to contribute to the development of metabolism-related diseases. The long-term impact of HFD may be mediated by epigenetic mechanisms, and indeed, HFD has been reported to induce DNA methylation changes in white adipose tissue (WAT) near metabolism related genes. However, previous studies [...]

By |2018-01-08T13:05:19+00:00juni 26th, 2017|Papers|Reacties uitgeschakeld voor Prolonged high-fat diet induces gradual and fat depot-specific DNA methylation changes in adult mice

Growing more positive with age: The relationship between reproduction and survival in aging flies

Experimental Gerontology | April 2017 | Abstract Populations of laboratory animals that are selected for increased lifespan often show negative correlated responses in early fecundity. However, late fecundity and/or total lifetime fecundity can be higher in the populations selected for increased lifespan. This has been interpreted by some as being at odds with the [...]

By |2018-01-08T13:06:00+00:00juni 20th, 2017|Papers|Reacties uitgeschakeld voor Growing more positive with age: The relationship between reproduction and survival in aging flies

Dietary acid load, trabecular bone integrity, and mineral density in an ageing population: the Rotterdam study

Osteoporosis International: with other metabolic bone diseases | 12-04-2017 | Abstract We studied the relation between a diet that is high in acid-forming nutrients (e.g. proteins) and low in base-forming nutrients (e.g. potassium) and bone structure. We showed a negative relation, which was more prominent if proteins were of animal rather than of [...]

By |2018-01-08T13:06:48+00:00juni 20th, 2017|Papers|Reacties uitgeschakeld voor Dietary acid load, trabecular bone integrity, and mineral density in an ageing population: the Rotterdam study

Protein-enriched familiar foods and drinks improve protein intake of hospitalized older patients: A randomized controlled trial

Cilincal Nutrition  | 12-05-2017 | Abstract Background & aims: Adequate protein intake is important in preventing and treating undernutrition. Hospitalized older patients are recommended to consume 1.2e1.5 g of protein per kg body weight per day (g/kg/d) but most of them fail to do so. Therefore, we investigated whether a range of newly [...]

By |2018-01-08T13:07:28+00:00juni 20th, 2017|Papers|Reacties uitgeschakeld voor Protein-enriched familiar foods and drinks improve protein intake of hospitalized older patients: A randomized controlled trial